SYNTHESIS AND IN VITRO ANTITUMOR ACTIVITY OF BENZIMIDAZOLE DERIVATIVES
Original Research Paper
Balram Soni1*,Mahendra Singh Ranawat1, Anil Bhandari2 and Rambabu Sharma2
1B.N.College of Pharmacy, Udaipur, Rajasthan-313 001, India
2Faculty of Pharmaceutical Sciences, Jodhpur National University,
Narnadi, Jodhpur, Rajasthan-342 003, India
One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with antitumor activity. Thus, a novel series of Schiff bases 1-11, the derivatives of 2-aryl-1H-benzimidazole has been synthesized and evaluated for their cytotoxic activity against the cells of human cancer cell lines, namely K-562 (myelogenous leukemia) and HL-60 (promyelocytic leukemia). Among the compounds tested against K-562 cell line, compounds 1, 7 and 10 showed potent activity and the compound 5 exhibited better activity against HL-60 cell line.
Keywords: 2-Aryl-1H-benzimidazole, Schiff bases, Leukemia, Antitumor activity.
International Journal of Drug Research and Technology