Overview Study on The Nutrition Value, Types and Beneficial Effect of Tea and Coffee

2026-03-04T09:17:58+0530

Both Tea and Coffee have been shown in several epidemiological research and clinical trials to have positive benefits on human health, including hepatoprotective, anti-obesity, anti-diabetic, antihypertensive, and anticancer properties. Additionally, cell-based and animal research corroborate these human findings. These effects have been linked to chlorogenic acid in coffee and epigallocatechin gallate in green tea. These compounds have been suggested to act through a variety of pathways, the most significant of which seems to involve reactive oxygen species. Both have opposing dual effects as prooxidants and antioxidants. By scavenging ROS, their antioxidative impact can cause nuclear factor-κB to be downregulated, which can result in a number of beneficial benefits, including anti-inflammatory effects and cancer cell death. The prooxidant effects, however, can enhance the formation of ROS, resulting in the activation of AMP-dependent protein kinase, which regulates various enzymes and factors that have advantageous functions. Currently, it is uncertain how they can be induced to function as either a prooxidant or an antioxidant, although the levels within cells, the existence of metal cations, and the cells' redox state seem to be significant factors. Significantly, numerous human studies failed to indicate the positive health benefits of coffee and green tea. The varying outcomes might have resulted from several confounding variables such as smoking, gut microbiota, and genetic influences. This chapter explores the existing knowledge regarding the qualities of green tea and coffee to enhance the comprehension of a method for enjoying a healthy longevity. Tea, originating in China, has reached every corner of the globe and has become the most enjoyed drink, following water. This review seeks to enhance current understanding by providing insights into the nutritional benefits of green tea and its pharmacological impacts on people. Moreover, its market share, patents, and formulations for nutraceuticals and pharmaceuticals are presented.

Repurposing Phenytoin and Its Derivatives for Ovarian Cancer Management: Current Insights and Future Directions

2026-03-29T14:20:22+0530

Ovarian cancer is one of the most serious gynecological malignancies because most patients are diagnosed at an advanced stage when treatment options become limited. Although surgery and chemotherapy remain the primary treatments, many patients eventually develop resistance to drugs such as cisplatin and paclitaxel, resulting in poor long-term outcomes. Drug repurposing has gained attention as an effective strategy because it allows the use of existing approved medicines for new therapeutic purposes, reducing both development time and cost. Phenytoin, traditionally used as an antiepileptic drug, has shown promising anticancer effects by blocking voltage-gated sodium channels, reducing tumor cell invasion, and inducing apoptosis in various cancer types. Hydantoin derivatives, structurally related to phenytoin, also demonstrate enhanced cytotoxicity and better molecular targeting. This review provides an overview of current insights into the potential role of phenytoin and its derivatives in managing ovarian cancer, highlighting their mechanisms of action, preclinical evidence, limitations, and future therapeutic opportunities.

International Journal of Pharmaceutical Research and Medicinal Plants

Overview Study on The Nutrition Value, Types and Beneficial Effect of Tea and Coffee

Repurposing Phenytoin and Its Derivatives for Ovarian Cancer Management: Current Insights and Future Directions