A REVIEW ON ACRIDINE, XANTHENE AND ITS DERIVATIVES: SYNTHESIS, PHYSICAL AND PHARMACOLOGICAL PROPERTIES

Authors

  • Herole RA Department of Pharmaceutical Chemistry, Institute of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagri, Jhunjhunu, Rajasthan-333001
  • Rakesh Kumar Jat Department of Pharmaceutical Chemistry, Institute of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagri, Jhunjhunu, Rajasthan-333001
  • Rajendra D Dighe Department of Pharmaceutical Chemistry, Institute of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagri, Jhunjhunu, Rajasthan-333001

Keywords:

Acridines, Xanthenes, Benzoacridine, Benzoxanthene, Docking, Alkaloids, Anticancer, Antibacterial

Abstract

Acridine derivatives are one of the oldest category of bioactive, globally used as anticancer, antiprotozoal agents and antibacterial. The class of acridine derivatives constitutes an interesting group of nitrogen-containing tricyclic compounds that caught the scientific group’s attention, mainly due to its wide range of pharmaceutical properties. The synthesis of new polycyclic acridine skeletons fused with a five or six-membered rings, have been extensively studied because they play important roles in some DNA-intercalating anticancer drugs. Benzoacridine derivatives have been recently synthesized by a number of methods via one-pot multi-component condensation reactions of dimedone, naphthylamines, and aldehydes in different conditions, for example, using triethylbenzylammonium chloride/H2O, ionic liquid, under microwave irradiation, or ultrasound irradiation. A xanthene is found to most multifaceted heterocyclic ring having as it is having variety of activity and utilization. Xanthine derivatives are medications used to treat bronchospasm caused by lung conditions such as asthma. Xanthenes dyes shows antiviral activity, anti-tubercular, anticancer, anti-microbial, malonate derivatives was having anti-spasmodic activity. Benzoxanthenes are tetracyclic dibenzopyrans with diverse biological and therapeutic properties such as antibacterial, antitumor, anti-inflammatory, antiviral, pesticidal activities, and antimalarial.

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Published

27-12-2022
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Herole RA, Rakesh Kumar Jat, and Rajendra D Dighe. “A REVIEW ON ACRIDINE, XANTHENE AND ITS DERIVATIVES: SYNTHESIS, PHYSICAL AND PHARMACOLOGICAL PROPERTIES”. Tropical Journal of Pharmaceutical and Life Sciences, vol. 9, no. 6, Dec. 2022, pp. 01-12, https://informativejournals.com/journal/index.php/tjpls/article/view/108.

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