Formulation and Evaluation of Paracetamol Tablet to Assess Binding Property of Limonia acidissima Pectin


  • Varsha C. Fegade Research Scholar, Shri. Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, India. Asssistant, Professor, Matoshri College of Pharmacy, Eklahare, Nashik, India.
  • Sachin B. Narkhede Smt. BNB Swaminarayan Pharmacy College, Salvav, Valsad, Gujrat, India
  • Rushabh Kumar Department of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, India



Pectin, Limonia acidissima, Binding Property, Water based extraction


Plants acts as a major source of medicines and are used to formulate various pharmaceutical preparations. Apart from this they act as excellent pharmaceutical aids and excipients.Limonia acidissima is nutritious, easily available, cheap but underutilized fruit. The aim of present research is to isolate the pectin from dried fruit pulp of Limonia acidissima and to assess its binding property. Pectin was extracted by boiling dried fruit pulp powder with water for 7 hrs at pH 3.2 adjusted with citric acid and using ethanol as precipitating agent.  Binding property of pectin was assessed using paracetamol as a model drug. Paracetamol granules were prepared by wet granulationmethod. Granules were prepared using starch as disintegrant, calcium carbonate as filler, talc as glidant, Magnesiumstearate as lubricant and varying concentration of pectin as binder and were compressed into respective tablets.A reference batch of starch as binder was prepared to carry out the comparative study and to assess the binding property of pectin. Total four batches of formulation were prepared using different concentrations of pectin. For each formulation pre compression and post compression studies were performed and compared to range asper pharmacopoeias. Tablets were evaluated based on Weight uniformity, Tablet Hardness, Friability, Disintegration and In vitro drug release. The results obtained for all pre-compression and post compression parameters were found within acceptable range of pharmacopoeias. Limonia acidissima pectin can act as excellent binder in dosage forms. In vitro dissolution studies were revealed that batch F3 showed 99.64 % of drug release. In pharmaceutical dosage form like tablet, Limonia acidissima pectin acts as an excellent binder since it is of natural origin and Limonia acidissima fruits were available easily at very low costand proved to be better alternative for synthetic binder.


Download data is not yet available.


Alphons G.J. Voragen, Gerd-jan Coenen, Rene P.Verhoef, Henk a Schols, Pectin, a versatile polysaccharide present in plant cell wall, structural chemistry, 2009, 20: 263-275.

Frederick W. A. Owusu, Mariam E. Boakye-Gyasi, Philomena Entsie, Marcel T. Bayor and Kwabena Ofori-Kwakye, Utilization of Pectin from Okra as Binding Agent in Immediate Release Tablets, BioMed Research International, 2021.

Kwabena Ofori-Kwakye, Frederic Osei-Yeboah, Samuel Lugrie Kipo, Formulation and Quality evaluation of two conventional release tablet formulation, International Journal of Pharmaceutical Sciences Review and Research, 2010, Vol.4(1),94-99.

M Ravindrakullai reddy, Kopparam Manjunath, Evaluation of Pectin derived from Orange peel as a Pharmaceutical Excipient, 2013, Vol.5(2), 283-294.

M. Padmaa Paarakh, Preethy Ani Jose, CM Setty, G. V. Peter Christopher, Release kinetics-Concepts and Applications, International Journal of Pharmacy Research and Technology, 2018, Vol.8, Pg. No. 12-20.

Mayank Bansal, Sumedha Bansal, Gopal Garg, Formulation and Evaluation of Immediate Release Tablets of Zaltoprofen, Scholars Academic Journal of Pharmacy, 2013; 2(5):398-405.

Nilesh. R. Khule, Nitin B. Mahale, Dipak S. Shelar, Manisha M. Rokade, Sanjay R. Chaudhari, Extraction of pectin from citrus fruit peel and use as natural binder in Paracetamol tablet, Der Pharmacia Lettre, 2012, 4 (2):558-564.

Pragyan Aparicita Patra, Uday Chand Basak, Physicochemical Characterization of Pectin Extracted From Six Wild Edible Fruits In Odisha, India, Current Research in Nutrition and Food Science, 2020, Vol. 08(2), Pg. 402-409.

Pranati Srivastava, Rishabha Malviya1, Giriraj T. Kulkarni, Formulation and Evaluation of Paracetamol tablets to assess binding property of Orange Peel Pectin, International Journal of Pharmaceutical Sciences Review and Research, 2010, Vol.3(1),30-34.

Rahul Sharma, Ayush Garg, Ranu Sharma, Vijay Singh Kachawa, Jayesh Dwivedi, A Brief Review on Tablet as A Dosage Form With Special Reference To Fast Dissolving Tablets, World Journal of Pharmaceutical and Life Sciences, 2015, Vol.8(8), 58-62.,

Sarath. S. Menon, B. V. Basavaraj, S. Bharath, R. Deveswaran and V. Madhavan, Formulation and evaluation of ibuprofen tablets using orange peel pectin as binding agent, Der Pharmacia Lettre, 2011: 3 (4) 241-247.

Subhashis Debnath, C. Navya Yadav, N. Nowjiya, M. Prabhavathi, A. SaiKumar, P. Sai Krishna, M. Niranjan Babu, A Review on Natural Binders used in Pharmacy, Asian Journal of Pharmaceutical Research, 2019, Vol.9(1), 55-60.

Supriya Sandhan, Nilima Thombre, Sagar Aher, Isolation and Evaluation of Starch from Musa paradiiaca Linn. as a binder in tablet, International Journal of Pharmaceutical Sciences and Research, 2017; Vol. 8(8): 3484-3491.

Swati Chavan, Suvarna Dhangar, Sandhya Borse, Vipul Jain, Laxmikant Borse, Sunil Pawar, Isolation of Pectin from Orange Peel and its use as Binder in Tablet Formulation, World Journal of Pharmacy and Pharmaceutical Sciences, 2017, Vol.6(4), 1964-1969.

Vaishnavi M. Kulkarni, Shubham B. Babare, Sanket K. Joshi, Sanjay G. Walode, Mithun Rudrapal, Anand P. Kakade, Vibhavari M. Chatur, Formulation and Evaluation of Paracetamol Tablets using Coconut Oil as a Binder, Journal of Drug Delivery and Therapeutics, 2022; 12(1-s):4-7.

Vijay J Kuma, O. P. Sati, Ranjit Singh, A potential natural tablet binder from Grewia Optiva, Der Pharmacia Lettre, 2011, 3(3):120-127.



How to Cite

Varsha C. Fegade, Sachin B. Narkhede, and Rushabh Kumar. “Formulation and Evaluation of Paracetamol Tablet to Assess Binding Property of Limonia Acidissima Pectin”. Tropical Journal of Pharmaceutical and Life Sciences, vol. 10, no. 5, Sept. 2023, pp. 01-11, doi:10.61280/tjpls.v10i5.142.
165 Views | Downloads



Research Article