In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis

Authors

  • Ms. Sowmya B.A Department of Pharmacology, East West College of Pharmacy, Bengaluru-91, Karnataka, India.
  • Dr. Satish Pavuluri Associate Professor, Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Churela, Jhunjhunu, Rajasthan.

DOI:

https://doi.org/10.61280/tjpls.v10i5.143

Keywords:

Anti-ulcer, Acid, H / K - ATPase, Saponaria officinalis, HCL

Abstract

For the treatment and prevention of illnesses and disorders, medicinal plants are recognized to contain conventional therapeutic substances. This study examined the potential of ethanol extracts of Saponaria officinalis to block H+/K+ ATPase and neutralize acids in order to determine whether they may be utilized to cure ulcers. In traditional medicine, the Saponaria officinalis is used to treat gastrointestinal disorders and inflammation. The acidity of the extract at a 1500 mg/ml concentration was much lower than that of conventional aluminium hydroxide + magnesium hydroxide (500mg), falling to 5.33 from 12.7. The ethanol extract of Saponaria officinalis at a concentration of 100μg, showed maximum percentage of inhibition of 67.17±1.96% as compared to omeprazole 71.47±0.52%, demonstrated the highest percentage of inhibition of the H+/K+ - ATPase. The results of this study suggest that Saponaria officinalis ethanol extract contains substances that can block enzymes and neutralize acids, making it a potential alternative treatment for digestive issues.

Downloads

Download data is not yet available.

References

Onoja SO, Chinagorom O, Ikpa CBC, Madubuike KG, Ezeigbo II, Ijioma SN, Anaga AO and Ezeja MI: Gastroprotective effects of methanol extract of Eremomastax speciosa leaf harvested in Southern part of Nigeria in rat. The EuroBiotech Journal 2018; 2(4): 200- 08.

Hamedi S, Arian AA and Farzaei MH: Gastroprotective effect of aqueous stem bark extract of Ziziphus jujuba L. Against HCl/ethanol-induced gastric mucosal injury in rats. Journal of Traditional Chinese Medicine 2015; 35: 666-70.

Khatib N, Angel G, Nayna H, Kumar JR. Gastroprotective activity of the aqueous extract from the roots of Daucus carota L in rats. International Journal of Research in Ayurveda and Pharmacy 2010 SeptOct;1(1):112-119.

Fegade H, Gigani Y, Vekaria A, et. al. Evaluation of ulcer protective effects of Ocimum sanctum and Zingiber officinalis as herbo-formulation for aspirin induced ulcerations in Albino rats. Der Pharmacia Sinica 2011;2(2):46-53.

Lanas A and Chan FKL: Peptic ulcer disease. Lancet 2017; 390: 613-24.

Debjit B, Chiranjib C, Tripathi KK, Pankaj and Kumar KPS: Recent trends of treatment and medication peptic ulcerative disorder. International Journal of Pharm Tech Research 2010; 2(1): 970-80

Malfertheiner P and Schulz C: Peptic Ulcer: Chapter Closed? Digestive Disease 2020; 38: 112-16

Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev, 2000 52: 673-751.

Fatima S., Ramesh C., Qureshi A S. In-vitro evaluation of antiulcer activity of a polyherbal mixture. IOSR Journal of Pharmacy, 2018, 8:12: 55-59.

Garad MC, Upadhya MA, Kokare DM and Itankar PR: Aerial parts of Enicostemma littorale Blume serve as antipyretic and antacid: in-vivo and in-vitro evaluations. Pharmacognosy Communication 2012; 2(3): 42-45.

Gupta RKP, Pradeepa and Hanumanthappa M: In-vitro antioxidant and H+, K+ - ATPase inhibition activities of Acalypha wilkesiana foliage extract. Journal of Pharmacy and BioAllied Sciences 2013; 5(3): 214-23.

Prasad K, et.al. Evaluation of antiulcer and in-vitro antioxidant activity of methanolic extract of Psidium guajava root in albino wistar rats. International Journal of Phytopharmacology 2014;5(1):59-67. [11].

MI Thabrew and LDAM Arawwawala. An overview of In vivo and In vitro models that can be used for evaluating Anti-Gastric ulcer potential of medicinal plants – Review Article. Austin Biology 2016;1(2):1- 9. [12].

Houshia OJ et al. Assessment of the value of the antacid contents of selected Palestinian plants. American Journal of Chemistry 2012;2(6):322-325.

Yadav P, Ganeshpurkar A and Rai G: In-vitro H+/K+ - ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Pharmacognosy Research 2012; 4(2): 123-26.

Published

16-09-2023

How to Cite

Ms. Sowmya B.A, and Dr. Satish Pavuluri. “In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis”. Tropical Journal of Pharmaceutical and Life Sciences, vol. 10, no. 5, Sept. 2023, pp. 12-17, doi:10.61280/tjpls.v10i5.143.
Statistics
208 Views | Downloads

Issue

Section

Research Article