In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis

Ms. Sowmya B.A; Dr. Satish Pavuluri

doi:10.61280/tjpls.v10i5.143

Ms. Sowmya B.A Department of Pharmacology, East West College of Pharmacy, Bengaluru-91, Karnataka, India.
Dr. Satish Pavuluri Associate Professor, Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Churela, Jhunjhunu, Rajasthan.

10.61280/tjpls.v10i5.143

Keywords:

Anti-ulcer, Acid, H / K - ATPase, Saponaria officinalis, HCL

Abstract

For the treatment and prevention of illnesses and disorders, medicinal plants are recognized to contain conventional therapeutic substances. This study examined the potential of ethanol extracts of Saponaria officinalis to block H+/K+ ATPase and neutralize acids in order to determine whether they may be utilized to cure ulcers. In traditional medicine, the Saponaria officinalis is used to treat gastrointestinal disorders and inflammation. The acidity of the extract at a 1500 mg/ml concentration was much lower than that of conventional aluminium hydroxide + magnesium hydroxide (500mg), falling to 5.33 from 12.7. The ethanol extract of Saponaria officinalis at a concentration of 100μg, showed maximum percentage of inhibition of 67.17±1.96% as compared to omeprazole 71.47±0.52%, demonstrated the highest percentage of inhibition of the H+/K+ - ATPase. The results of this study suggest that Saponaria officinalis ethanol extract contains substances that can block enzymes and neutralize acids, making it a potential alternative treatment for digestive issues.

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