STABILITY AND BIODISTRIBUTION STUDY OF QUININE HYDROCHLORIDE NIOSOMAL FORMULATION

Abstract

Niosomal formulation found to be one of the promising approach to treat the malaria. QH loaded niosomal formulation used for the targeting the liver stages of the parasite to treat early stage malaria. The biodistribution pattern says that the QH loaded niosomes minimized the toxicity associated with plain QH solution, as were at the liver for longer period of time. Longer circulation of the niosomes showed that, incorporation of QH into the niosomes helped to increase the stability of QH by preventing it from chemical and enzymatic degradation. Lyophilized niosomal formulation (Proniosomes) were stable when stored at both refrigerated and room temperature.