FORMULATION, DEVELOPMENT AND EVALUATION OF CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEM FOR THE TREATMENT OF NOCTURNAL ASTHMA BY USING SALBUTAMOL SULPHATE MICROSPHERE
Keywords:
Salbutamol sulphate, Chronotherapeutics, Nocturnal Asthma , MicrosphereAbstract
Asthma can show noticeable daily fluctuations. Patients usually have symptoms that appear mainly during sleep, and even when symptoms occur during the day, they usually worsen at night. Deaths from asthma also usually occur at night or in the early morning. The rational of this study is to design and evaluate an oral site-specific, pulsatile drug delivery system containing Salbutamol Sulphate, which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal asthma. In the present research work, we have attempted to develop a novel dosage form by using a chronopharmaceutical approach. A microsphere dosage form, taken at bed time with a programmed start of drug release early in morning hours, can prevent a sharp increase in the incidence of asthmatic attacks, during the early morning hours (nocturnal asthma), a time when the risk of asthmatic attacks is the greatest.
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