Analysing Oxadiazole Derivatives for Their Anticancer Activity: A Review (Short Communication)
Keywords:
Cancer, Oxadiazole derivatives, Anticancer activity, Pharmacological properties, Preclinical studies, Clinical trials, Mechanisms of actionAbstract
Innovative ways are needed to effectively treat cancer, which continues to be one of the most difficult medical problems of our day. A new class of chemicals with promising cancer therapeutic potential has evolved in the last few years: oxadiazole derivatives. This study summarizes what is now known about oxadiazole-based medications, including how they work, what their pharmacological characteristics are, and what we have learned from recent advances in both clinical and preclinical research.
Downloads
References
Benassi, A., Doria, F., & Pirota, V. (2020). Groundbreaking anticancer activity of highly diversified oxadiazole scaffolds. International journal of molecular sciences, 21(22), 8692.
Vaidya, A., Pathak, D. and Shah, K., 2021. 1, 3, 4‐oxadiazole and its derivatives: A review on recent progress in anticancer activities. Chemical biology & drug design, 97(3), pp.572-591.
Nayak, Swarnagowri, Santosh L. Gaonkar, Ebraheem Abdu Musad, and Abdullah Mohammed AL Dawsar. "1, 3, 4-Oxadiazole-containing hybrids as potential anticancer agents: Recent developments, mechanism of action and structure-activity relationships." Journal of Saudi Chemical Society 25, no. 8 (2021): 101284.
Vaidya, A., Jain, S., Jain, P., Jain, P., Tiwari, N., Jain, R., Jain, R., K Jain, A. and K Agrawal, R., 2016. Synthesis and biological activities of oxadiazole derivatives: A review. Mini Reviews in Medicinal Chemistry, 16(10), pp.825-845.
Tiwari, D. and Narang, R., 2021. A review on microwave assisted synthesis, mechanism of action and structure activity relationship of 1, 3, 4-oxadiazole derivatives as anticancer agent. World Journal of Advanced Research and Reviews, 9(1), pp.086-096.
Benassi, Alessandra, Filippo Doria, and Valentina Pirota. "Groundbreaking anticancer activity of highly diversified oxadiazole scaffolds." International journal of molecular sciences 21, no. 22 (2020): 8692.
Hatti, I., Sreenivasulu, R., Jadav, S. S., Ahsan, M. J., & Raju, R. R. (2015). Synthesis and biological evaluation of 1, 3, 4-oxadiazole-linked bisindole derivatives as anticancer agents. Monatshefte für Chemie-Chemical Monthly, 146, 1699-1705.
Salama, E. E., Althobaiti, I. O., Haukka, M., & Boraei, A. T. (2022). Synthesis, X-ray Single-Crystal Analysis, and Anticancer Activity Evaluation of New Alkylsulfanyl-Pyridazino [4, 5-b] indole Compounds as Multitarget Inhibitors of EGFR and Its Downstream PI3K-AKT Pathway. Crystals, 12(3), 353.
Kadambar, A. K., Kalluraya, B., Singh, S., Agarwal, V., & Revanasiddappa, B. C. (2021). One‐pot three‐component azide‐alkyne cycloaddition: Synthesis of new pyrazole, 1, 2, 3‐triazole, and oxadiazole tethered and their anti‐inflammatory, quantitative structure‐activity relationship, and docking studies. Journal of Heterocyclic Chemistry, 58(2), 654-664.
Singhai, A., & Gupta, M. K. (2020). Synthesis and characterization of 1, 3, 4-oxadiazole derivatives as potential anti-inflammatory and analgesic agents. Research Journal of Pharmacy and Technology, 13(12), 5898-5902.
Naclerio, George A., et al. "N-(1, 3, 4-oxadiazol-2-yl) benzamides as antibacterial agents against Neisseria gonorrhoeae." International journal of molecular sciences 22.5 (2021): 2427.
Fathi, Marwa Ali A., et al. "1, 3, 4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities." Bioorganic chemistry 84 (2019): 150-163.
Rawat, Bhupender Singh, Shrawan Kumar Shukla, Nidhi Gangwar, Roopali Tandon, and S. C. Mehra. "Synthesis Characterization and Anti-Inflammatory Activities of Substituted Aniline Oxadiazolyl Derivatives." Int J Sci Res Sci, Eng Technol 3, no. 5 (2017): 290-295.
Tiwari, A., Gopalan Kutty, N., Kumar, N., Chaudhary, A., Vasanth Raj, P., Shenoy, R., & Mallikarjuna Rao, C. (2016). Synthesis and evaluation of selected 1, 3, 4-oxadiazole derivatives for in vitro cytotoxicity and in vivo anti-tumor activity. Cytotechnology, 68, 2553-2565.
Alhadad, Khaldoon S., Rita S. Elias, Husam Hamza Salman, and Rawaa MO. "Synthesis, Characterization and Antimicrobial Evaluation of Some New 1, 3, 4-oxadiazoline Compounds." Journal of Global Pharma Technology 12, no. 01 (2009).
Harish, Kikkeri P., Kikkeri N. Mohana, Lingappa Mallesha, and Bantal Veeresh. "Synthesis and In Vivo Anticonvulsant Activity of 2‐Methyl‐2‐[3‐(5‐piperazin‐1‐yl‐[1, 3, 4] oxadiazol‐2‐yl)‐phenyl]‐propionitrile Derivatives." Archiv der Pharmazie 347, no. 4 (2014): 256-267.
Çevik, Ulviye Acar, Derya Osmaniye, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlik, Serkan Levent, Sinem Ilgin, Nafiz Öncü Can, Yusuf Özkay, and Zafer Asım Kaplancikli. "Synthesis of novel benzimidazole–oxadiazole derivatives as potent anticancer activity." Medicinal Chemistry Research 28 (2019): 2252-2261.
Zhang, Xiao-Min, Min Qiu, Juan Sun, Yan-Bin Zhang, Yu-Shun Yang, Xiao-Liang Wang, Jian-Feng Tang, and Hai-Liang Zhu. "Synthesis, biological evaluation, and molecular docking studies of 1, 3, 4-oxadiazole derivatives possessing 1, 4-benzodioxan moiety as potential anticancer agents." Bioorganic & medicinal chemistry 19, no. 21 (2011): 6518-6524.
Mendes Araujo, H., de Moura, G.A., Mendes Rocha, Y., Viana Rodrigues, J.P. and Nicolete, R., 2023. Oxadiazole Derivatives as Anticancer and Immunomodulatory Agents: A Systematic Review. Current Medicinal Chemistry, 30(30), pp.3472-3485.
Published
How to Cite
Issue
Section
Copyright (c) 2026 Vishnu Kumar Yadav , Piush Sharma, Pramod Kumar Goyal, Sanwar Mal Yadav
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright Policy & Licensing terms | Tropical Journal of Pharmaceutical and Life Sciences
