SYNTHESIS AND EVALUATION OF ANTIFUNGAL ACTIVITY OF  4, 6-DIPHENYL-3, 4- DIHYDROPYRIMIDINE-2-(1H)-ONE DERIVATIVES

Vishal Garg; Dinesh Jindal; Rambir Singh

doi:10.61280/tjpls.v7i6.45

SYNTHESIS AND EVALUATION OF ANTIFUNGAL ACTIVITY OF 4, 6-DIPHENYL-3, 4- DIHYDROPYRIMIDINE-2-(1H)-ONE DERIVATIVES

Vishal Garg Jaipur School of Pharmacy Maharaj Vinayak Global University, Dhand Amer, Jaipur
Dinesh Jindal Department Pharmaceutical Chemistry, Jaipur School of Pharmacy Maharaj Vinayak Global University, Dhand Amer, Jaipur
Rambir Singh Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India

10.61280/tjpls.v7i6.45

Keywords:

Pyrimidine derivative, Antifungal activity, Aspergillus niger, Candida albicans.

Abstract

In the present work was designed to synthesize and evaluate the antifungal activity of 4, 6-diphenyl-3, 4- dihydropyrimidine-2-(1H)-one derivatives. The 3, 4- dihydropyrimidin 2 (1H)-one was used as nucleus for the synthesis of N-mannich bases of pyrimidine derivatives. All synthesized intermediates and products were identified on the basis of melting point range, Rf value, Elemental analysis, and IR spectral analysis. The synthesized compounds were screened for their antifungal activity against Candida albicans (MTCC 227) and Aspergillus niger (MTCC 282) in Sabouraud’s dextrose agar medium using fluconazole as a standard drug.

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Published

10-12-2020

How to Cite

Garg, V., D. Jindal, and R. Singh. “SYNTHESIS AND EVALUATION OF ANTIFUNGAL ACTIVITY OF 4, 6-DIPHENYL-3, 4- DIHYDROPYRIMIDINE-2-(1H)-ONE DERIVATIVES”. Tropical Journal of Pharmaceutical and Life Sciences, vol. 7, no. 6, Dec. 2020, pp. 08-12, doi:10.61280/tjpls.v7i6.45.