Pharmacokinetic and Bio-Distribution Study of Purified Fractions of Celery Extract in Rats

Vishal Vasantrao  Kshirsagar; Dr Rakesh Kumar  Jat

doi:10.61280/tjpls.v10i4.127

Vishal Vasantrao Kshirsagar Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu , India
Dr Rakesh Kumar Jat Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu , India

DOI: https://doi.org/10.61280/tjpls.v10i4.127

Keywords:

Pharmacokinetic, Biodistribution study, Purified fractions, Celery extract, Medicinal Plants

Abstract

Introduction: The ethnic people cultures and traditions anywhere in the globe, ritual, legends, myths, folksongs, and medicinal practices.

Aim of the study: The main aim of the study is pharmacokinetic and bio-distribution study of purified fractions of celery extract in rats.

Material and method: The dosages of TA (Aq) and TA (Ethanol) that were used for the research were 2000 mg/kg at step 2 and repeat of 2000 mg/kg at step 2. Each day's dose of test material was formulated just before administration.

Conclusion: The results of the present study can be a useful lead for further investigation on SE, to evaluate the efficacy in management of Diabetes mellitus and its complications.

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Author Biographies

Vishal Vasantrao Kshirsagar, Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu , India

Scholar

Institute of Pharmacy

Dr Rakesh Kumar Jat, Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu , India

Principal

Institute of Pharmacy, SJJT University,

Jhunjhunu, India

References

Ahmed, B., T. Alam, M. Varshney and S. A. Khan (2002). "Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family." Journal of Ethnopharmacology 79(3): 313-316.

Ahmed, S. S. S. J. and V. Ramakrishnan (2012). "Systems Biological Approach of Molecular Descriptors Connectivity: Optimal Descriptors for Oral Bioavailability Prediction." PLOS ONE 7(7): e40654.

Akbari, M. and V. Hassan-Zadeh (2018). "Hyperglycemia Affects the Expression of Inflammatory Genes in Peripheral Blood Mononuclear Cells of Patients with Type 2 Diabetes." Immunol Invest 47(7): 654-665.

Al-Asmari, A. K., M. T. Athar and S. G. Kadasah (2017). "An Updated Phytopharmacological Review on Medicinal Plant of Arab Region: Apium graveolens Linn." Pharmacognosy reviews 11(21): 13-18.

Al-Howiriny, T., A. Alsheikh, S. Alqasoumi, M. Al-Yahya, K. ElTahir and S. Rafatullah (2010). "Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats." Pharm Biol 48(7): 786-793.

Al-Sa'aidi, J., M. Alrodhan and K. Ismael (2012). "Antioxidant activity of n-butanol extract of celery (Apium graveolens) seed in streptozotocin-induced diabetic male rats." 4: 24-29.

Alhowiriny, T., A. Alsheikh, S. Alqasoumi, M. Al-Yahya, K. ElTahir and S. Rafatullah (2010). "Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium Graveolens) in rats." Pharmaceutical biology 48: 786-793.

Ali, R. A. (2003). "Management of diabetic neuropathy." The Malaysian journal of medical sciences : MJMS 10(2): 27-30.

American Diabetes, A. (2009). "Diagnosis and classification of diabetes mellitus." Diabetes care 32 Suppl 1(Suppl 1): S62-S67.

Amir-Aslani, A. and V. Mangematin (2010). "The future of drug discovery and development: Shifting emphasis towards personalized medicine." Technological Forecasting and Social Change 77(2): 203-217.