SYNTHESIS AND EVALUATION OF ANTIFUNGAL ACTIVITY OF 4, 6-DIPHENYL-3, 4- DIHYDROPYRIMIDINE-2-(1H)-ONE DERIVATIVES

Abstract

In the present work was designed to synthesize and evaluate the antifungal activity of    4, 6-diphenyl-3, 4- dihydropyrimidine-2-(1H)-one derivatives. The 3, 4- dihydropyrimidin 2 (1H)-one was used as nucleus for the synthesis of N-mannich bases of pyrimidine derivatives. All synthesized intermediates and products were identified on the basis of melting point range, Rf value, Elemental analysis, and IR spectral analysis. The synthesized compounds were screened for their antifungal activity against Candida albicans (MTCC 227) and Aspergillus niger (MTCC 282) in Sabouraud’s dextrose agar medium using fluconazole as a standard drug.