Evaluation of In-Vivo Analgesic and Antipyretic Potential of Indigofera tinctoria in Albino Wistar Rats

Dr Praveen Kumar Goyal; Dr Gurpreet Singh

doi:10.61280/journalmedicinalplants.v1i3.216

Dr Praveen Kumar Goyal Alwar Pharmacy College, Alwar (Rajasthan), India
Dr Gurpreet Singh Alwar Pharmacy College, Alwar (Rajasthan), India

DOI: https://doi.org/10.61280/journalmedicinalplants.v1i3.216

Keywords:

Indigofera tinctoria, Analgesic, Pyrexia, Paracetamol, Leaves

Abstract

Objective: The leaves of the Indigofera tinctoria plant has not been studied for its potential antipyretic, anti-inflammatory, or analgesic effects. Thus, the purpose of the current research is to support the traditional usage of this plant by scientifically evaluating these aforementioned actions of the plant I tinctoria on experimental animals

Methods: Fever was induced by injecting 10ml/Kg (subcutaneous) of 0.5(w/v) suspension of brewer’s yeast in Carboxy methylcellulose below the nape of the neck. Analgesic activity in rats determined by hot-plate method.

Results: The initial and final rectal temperatures (°C) in the group treated with ethanol extract (200 mg/kg body weight) and ethanol extract (400 mg/kg body weight) were found to be 37.75±0.04 and 37.70±0.07 respectively, compared to 37.64±0.12 in paracetamol (reference drug) treated group. For analgesic potential the result shows that the latency period of ethanolic leaves extract 200 and 400 mg/kg was significantly good when compared to control (p<0.001).Conclusion: The result of the present preliminary study confirmed the antipyretic and analgesic activity of I tinctoria in rats. However, further investigation is required to separate the active fraction(s)/constituent(s) responsible for the activity and to ascertain the mechanism(s) of action.

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