Pharmacognostic Standardization, Phytochemical Evaluation And Anti-Pyretic Activity Of Tectona Grandis Leaf Extracts
DOI:
https://doi.org/10.61280/1pxb2n13Keywords:
Tectona grandis, Standardization, Phytochemical analysis, Thin Layer Chromatography, Anti-pyretic activityAbstract
This study evaluates the pharmacognostic, physicochemical, phytochemical, and pharmacological properties of Tectona grandis (Teak) leaves. Quantitative microscopy established key plant constants including vein-islet number (8/sq mm), vein-termination number (6/sq mm), palisade ratio (7), stomatal numbers, and stomatal indices. Extractive values varied across solvents, with ethanol yielding the highest percentage (12.45% w/w). Proximate parameters showed a loss on drying of 4.55%, total ash of 6.85%, and foreign organic matter of 1.2%. Quantitative phytochemical analysis revealed a Total Phenol Content (TPC) of 24.7 mg/g GAE and Total Flavonoid Content (TFC) of 10.45 mg/g Quercetin equivalents, with qualitative tests confirming high concentrations of terpenoids and flavonoids in the ethanol extract. Furthermore, the ethanolic extract of Tectona grandis (EETG) demonstrated significant, dose-dependent anti-pyretic activity in Brewer's yeast-induced pyrexia in rats, particularly at doses of 200 mg/kg and 400 mg/kg, performing comparably to the reference drug paracetamol (30mg/kg). These effects are likely mediated via the inhibition of prostaglandin synthesis.
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