Comparison of Different Superdisintegrants In Designing of Mouth Dissolving Tablets of Domperidone

Gurpreet Singh; Rajesh Sharma; Praveen Kumar Goyal

doi:10.61280/journalmedicinalplants.v1i3.217

Gurpreet Singh Alwar Pharmacy College, Alwar, Rajasthan, India
Rajesh Sharma Alwar Pharmacy College, Alwar, Rajasthan, India
Praveen Kumar Goyal Alwar Pharmacy College, Alwar, Rajasthan, India

DOI: https://doi.org/10.61280/journalmedicinalplants.v1i3.217

Keywords:

Mouth dissolving tablets, Domperidone, Superdisintegrants

Abstract

This research involves preparation of mouth dissolving tablets of of Domperidone by direct compression method using various concentrations of superdisintegrants sodium starch glycolate, croscarmellose and crospovidone (D1 – D9). The tablets were evaluated for parameters like thickness, hardness, friability, In vitro & In vivo disintegration time, wetting time, water absorption ratio, % drug content and In vitro drug release studies. Based on the results, formulation containing 6% superdisintegrants in combination (CCS, CP & SSG) (D-2) was identified as ideal and better formulation among all formulations developed for Domperidone Maleate tablets. In vitro release of optimized formulation of Domperidone Maleate Mouth dissolving tablets of D-2 was found to be 99.43% drug release within 10minutes and in-vitro disintegration time being ranges between 40 and 42sec. The final optimized formulation (D-2) was compared with marketed product of Domperidone Maleate tablets (DOMSTAL-MT) which shows 94.22% drug release in 10 minutes. It means the prepared formulation show quite satisfactory release with compared to Marketed Product.

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Author Biographies

Gurpreet Singh, Alwar Pharmacy College, Alwar, Rajasthan, India

Professor

Department of Pharmaceutics

Rajesh Sharma, Alwar Pharmacy College, Alwar, Rajasthan, India

Professor

Department of Pharmaceutics

Praveen Kumar Goyal, Alwar Pharmacy College, Alwar, Rajasthan, India

Professor

Department of Pharmacognosy,

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